How did we get here, where are we going, how does this amazing universe function, and how can we survive the next billion years?  Our next 50 years of scientific discovery can only be guessed, but numerous National Academy reports tell us the open questions, and there are many strategies to meet them.  We could perhaps: see how the first stars were made, see how solar systems are made, find dark matter in a laboratory, measure the dark energy that makes the expanding universe accelerate, measure gravitational waves from awesome cosmic explosions, find signs of gravitational waves in the Big Bang itself, see if Einstein’s theory of gravity really describes black holes, find life on Mars or Europa or Ganymede, or on planets around some other distant star. Or closer to home, maybe we’ll know when and how the Sun will erupt, how it affects the Earth, how fast our climate is changing and why and what to do about it, and how to protect ourselves from rocks falling on us from space.  Maybe, we’ll even find out how life could have started, and maybe our biologist friends will make some live things from basic building blocks in a test tube.  Or maybe, we’ll make some form of digital life, that will transform the way we live, or how we travel through the solar system and out into the universe.  My crystal ball is quivering!